N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide

Base Information

• Chemical Name: N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide
• CAS No.: 196198-67-1
• Molecular Formula: C₂₅H₂₈N₆O₇
• Molecular Weight: 524.533

Synonyms:

Chemical Property of N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide

There total 12 articles about N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-8-nitroisoquinoline (63927-23-1) → N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide (196198-67-1)

Guidance literature:

Multi-step reaction with 12 steps

1: 1.) CH₃SO₃H, 2.) NaCNBH₃ / 1.) CHCl₃, 2.) HCOOH

3: H₂ / RaNi

5: HONO₂ / trifluoroacetic acid

6: 3 N HCl / Heating

7: H₂ / 20percent Pd-C

8: 3 N HCl / Heating

9: HONO₂ / trifluoroacetic acid

10: NEt₃ / dimethylformamide / 60 °C

11: 1 N NaOH / tetrahydrofuran

12: EDAC, HOBT, NEt₃ / dimethylformamide

With hydrogenchloride; sodium hydroxide; methanesulfonic acid; hydrogen; nitric acid; sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1016/S0960-894X(97)00344-2

Reference yield:

5-Bromo-1,2,3,4-tetrahydro-8-nitroisoquinoline (156694-04-1) → N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide (196198-67-1)

Guidance literature:

Multi-step reaction with 11 steps

2: H₂ / RaNi

4: HONO₂ / trifluoroacetic acid

5: 3 N HCl / Heating

6: H₂ / 20percent Pd-C

7: 3 N HCl / Heating

8: HONO₂ / trifluoroacetic acid

9: NEt₃ / dimethylformamide / 60 °C

10: 1 N NaOH / tetrahydrofuran

11: EDAC, HOBT, NEt₃ / dimethylformamide

With hydrogenchloride; sodium hydroxide; hydrogen; nitric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1016/S0960-894X(97)00344-2

Reference yield:

1-(8-Amino-5-bromo-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone (183545-96-2) → N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide (196198-67-1)

Guidance literature:

Multi-step reaction with 9 steps

2: HONO₂ / trifluoroacetic acid

3: 3 N HCl / Heating

4: H₂ / 20percent Pd-C

5: 3 N HCl / Heating

6: HONO₂ / trifluoroacetic acid

7: NEt₃ / dimethylformamide / 60 °C

8: 1 N NaOH / tetrahydrofuran

9: EDAC, HOBT, NEt₃ / dimethylformamide

With hydrogenchloride; sodium hydroxide; hydrogen; nitric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1016/S0960-894X(97)00344-2

upstream raw materials:

tyrosamine

4-[2-(6-Nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyric acid

5-bromo-8-nitroisoquinoline

5-Bromo-1,2,3,4-tetrahydro-8-nitroisoquinoline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 196198-67-1 N-[2-(4-Hydroxy-phenyl)-ethyl]-4-[2-(6-nitro-2,3-dioxo-1,2,3,4,7,10-hexahydro-8H-pyrido[3,4-f]quinoxalin-9-yl)-acetylamino]-butyramide

Send

Send

Metric Ton KG G Pound L ML

Send

Send