2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid methyl ester
• CAS No.: 1228839-21-1
• Molecular Formula: C₃₁H₃₈FNO₄S
• Molecular Weight: 539.711

Synonyms:

Chemical Property of 2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid methyl ester

Chemical Property:

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Useful:

Technology Process of 2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid methyl ester

There total 1 articles about 2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-methyl-2'-{(1R)-1-[(2R)-oxiran-2-yl methoxy]ethyl}biphenyl-4-carboxylate (787585-28-8) + 2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamine (1228839-19-7) → 2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid methyl ester (1228839-21-1)

Guidance literature:

With lithium perchlorate; In toluene; at 50 ℃;

DOI:10.1021/ml100058w

Reference yield:

2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid methyl ester (1228839-21-1) → 2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid (1228839-23-3)

Guidance literature:

With water; lithium hydroxide; In methanol; at 50 ℃; for 16h;

DOI:10.1021/ml100058w

upstream raw materials:

methyl 3-methyl-2'-{(1R)-1-[(2R)-oxiran-2-yl methoxy]ethyl}biphenyl-4-carboxylate

2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamine

Downstream raw materials:

2'-((R)-1-{(R)-3-[2-(3-fluoro-4-methylsulfanyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-3-methyl-biphenyl-4-carboxylic acid

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