(+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis

Base Information

• Chemical Name: (+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis
• CAS No.: 141380-89-4
• Molecular Formula: C₃₀H₅₆N₆O₁₃P₄
• Molecular Weight: 832.702

Synonyms:

Chemical Property of (+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis

There total 3 articles about (+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid bis(p-nitrophenyl ester) (33109-58-9) + [(S)-2-(4-Amino-butyl)-4,7,10-tris-(hydroxy-methyl-phosphinoylmethyl)-1,4,7,10-tetraaza-cyclododec-1-ylmethyl]-methyl-phosphinic acid (141380-88-3) → (+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis (141380-89-4)

Guidance literature:

With 4-methyl-morpholine; In dimethyl sulfoxide; at 45 ℃; for 4h; Yield given;

DOI:10.1055/s-1992-34177

Reference yield:

(+)-(2S)-2-(4-benzamidobutyl)-1,4,7,10-tetra-azacyclododecane (123472-54-8) → (+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis (141380-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / molecular sieves (3 A) / tetrahydrofuran / 16 h / Heating

2: 6M HCl / Heating

3: N-methylmorpholine / dimethylsulfoxide / 4 h / 45 °C

With 4-methyl-morpholine; hydrogenchloride; 3 A molecular sieve; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1055/s-1992-34177

Reference yield:

[(S)-2-(4-Benzoylamino-butyl)-4,7,10-tris-(ethoxy-methyl-phosphinoylmethyl)-1,4,7,10-tetraaza-cyclododec-1-ylmethyl]-methyl-phosphinic acid ethyl ester (132610-06-1) → (+)-(2S)-2-<4-<3-(p-nitrophenoxycarbonyl)propionamido>butyl>-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis (141380-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 6M HCl / Heating

2: N-methylmorpholine / dimethylsulfoxide / 4 h / 45 °C

With 4-methyl-morpholine; hydrogenchloride; In dimethyl sulfoxide;

DOI:10.1055/s-1992-34177

upstream raw materials:

succinic acid bis(p-nitrophenyl ester)

[(S)-2-(4-Amino-butyl)-4,7,10-tris-(hydroxy-methyl-phosphinoylmethyl)-1,4,7,10-tetraaza-cyclododec-1-ylmethyl]-methyl-phosphinic acid

(+)-(2S)-2-(4-benzamidobutyl)-1,4,7,10-tetra-azacyclododecane

[(S)-2-(4-Benzoylamino-butyl)-4,7,10-tris-(ethoxy-methyl-phosphinoylmethyl)-1,4,7,10-tetraaza-cyclododec-1-ylmethyl]-methyl-phosphinic acid ethyl ester

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