Boc-Tyr-Met-Gly-Trp-Met-Asp-OH

Base Information

Chemical Name:Boc-Tyr-Met-Gly-Trp-Met-Asp-OH
CAS No.:113709-84-5
Molecular Formula:C₄₁H₅₄N₇O₁₅S₃*Na
Molecular Weight:1004.11
Hs Code.:

Synonyms:

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Chemical Property of Boc-Tyr-Met-Gly-Trp-Met-Asp-OH

Chemical Property:

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Technology Process of Boc-Tyr-Met-Gly-Trp-Met-Asp-OH

There total 12 articles about Boc-Tyr-Met-Gly-Trp-Met-Asp-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 113709-84-5
Boc-Tyr-Met-Gly-Trp-Met-Asp-OH

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) triethylamine; 2.) DCC, HOBt / 1.) 0 degC, 30 min; 2.) overnight, 8 degC

2: 80 percent / hydrazine hydrate / propan-1-ol / 96 h / Ambient temperature

3: 5.6 N HCl, isoamyl nitrite / dioxane; dimethylformamide / 0.5 h / -30 - -20 °C

4: 63.6 percent / triethylamine / dimethylformamide / 48 h / 8 °C

5: 64 percent / 1 N NaOH / methanol / 5 h / Ambient temperature

6: thioanisole / 1 h / 0 °C

7: 1.) triethylamine / 1.) DMF, 0 degC, 20 min; 2.) DMF, 7 d, 8 degC

8: 1.) pyridine-sulfur trioxide complex; 2.) 10percent sodium bicarbonate / 1.) 2 d, 8 degC; 2.) 0 degC, 30 min

With hydrogenchloride; sodium hydroxide; methyl-phenyl-thioether; sulfur trioxide pyridine complex; sodium hydrogencarbonate; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; isopentyl nitrite; In 1,4-dioxane; methanol; propan-1-ol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.4307

Reference yield:

: 23446-03-9
2-((2S)-2-((tert-butoxycarbonyl)amino)-4-(methylthio)butanamido)acetic acid

: 113709-84-5
Boc-Tyr-Met-Gly-Trp-Met-Asp-OH

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) triethylamine; 2.) DCC, HOBt / 1.) 0 degC, 30 min; 2.) overnight, 8 degC

2: 80 percent / hydrazine hydrate / propan-1-ol / 96 h / Ambient temperature

3: 5.6 N HCl, isoamyl nitrite / dioxane; dimethylformamide / 0.5 h / -30 - -20 °C

4: 63.6 percent / triethylamine / dimethylformamide / 48 h / 8 °C

5: 64 percent / 1 N NaOH / methanol / 5 h / Ambient temperature

6: thioanisole / 1 h / 0 °C

7: 1.) triethylamine / 1.) DMF, 0 degC, 20 min; 2.) DMF, 7 d, 8 degC

8: 1.) pyridine-sulfur trioxide complex; 2.) 10percent sodium bicarbonate / 1.) 2 d, 8 degC; 2.) 0 degC, 30 min

With hydrogenchloride; sodium hydroxide; methyl-phenyl-thioether; sulfur trioxide pyridine complex; sodium hydrogencarbonate; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; isopentyl nitrite; In 1,4-dioxane; methanol; propan-1-ol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.4307

Reference yield:

: 16948-13-3
Boc-Met-OTcp

: 113709-84-5
Boc-Tyr-Met-Gly-Trp-Met-Asp-OH

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) triethylamine / 1.) DMF, 0 degC, 30 min; 2.) DMF, 3 d, 8 degC

2: 542 mg / thioanisole / 1 h / 0 °C

3: 63.6 percent / triethylamine / dimethylformamide / 48 h / 8 °C

4: 64 percent / 1 N NaOH / methanol / 5 h / Ambient temperature

5: thioanisole / 1 h / 0 °C

6: 1.) triethylamine / 1.) DMF, 0 degC, 20 min; 2.) DMF, 7 d, 8 degC

7: 1.) pyridine-sulfur trioxide complex; 2.) 10percent sodium bicarbonate / 1.) 2 d, 8 degC; 2.) 0 degC, 30 min

With sodium hydroxide; methyl-phenyl-thioether; sulfur trioxide pyridine complex; sodium hydrogencarbonate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.4307