2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride

Base Information

Chemical Name:2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride
CAS No.:93852-13-2
Molecular Formula:C₂₀H₂₄N₂O₄*ClH
Molecular Weight:392.882
Hs Code.:

Synonyms:

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Chemical Property of 2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride

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Technology Process of 2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride

There total 15 articles about 2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10606-73-2,99531-04-1,116836-53-4,4773-33-5
ethyl 2-chloro-2-phenylacetate

: 93852-13-2,93852-61-0
2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

8: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

9: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;

Reference yield:

: 90-05-1
2-methoxy-phenol

: 93852-13-2,93852-61-0
2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: 1.) carbonyl-diimidazole; 2.) nitromethane Na salt / 1.) THF, reflux, 1 h; 2.) THF, reflux, 16 h

4: 72 percent / H₂, H₂SO₄ / PtO₂ / acetic acid / 0.67 h / 1900 Torr

5: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

6: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

7: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium hydroxide; Carbonyldiimidazole; sulfuric acid; potassium tert-butylate; hydrogen; sodium nitromethane; sodium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; platinum(IV) oxide; In methanol; dichloromethane; acetic acid; toluene; tert-butyl alcohol;

Reference yield:

: 53498-61-6
(2-Methoxy-phenoxy)-phenyl-acetic acid

: 93852-13-2,93852-61-0
2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid methylamide; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) carbonyl-diimidazole; 2.) nitromethane Na salt / 1.) THF, reflux, 1 h; 2.) THF, reflux, 16 h

2: 72 percent / H₂, H₂SO₄ / PtO₂ / acetic acid / 0.67 h / 1900 Torr

3: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

4: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

5: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With Carbonyldiimidazole; sulfuric acid; potassium tert-butylate; hydrogen; sodium nitromethane; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; platinum(IV) oxide; In dichloromethane; acetic acid; toluene; tert-butyl alcohol;