(2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester

Base Information

Chemical Name:(2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester
CAS No.:1025903-77-8
Molecular Formula:C₂₉H₃₃F₄N₇O₇
Molecular Weight:667.617
Hs Code.:

(2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester

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Chemical Property of (2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester

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Technology Process of (2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester

There total 1 articles about (2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32563-25-0,149117-03-3,91383-48-1,91383-47-0
(2S,4S)-L-threo-4-fluoroglutamic acid

: 1025903-77-8
(2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / H₂SO₄ / CHCl₃ / 96 h / Ambient temperature

2: DCC, HOBt / dimethylformamide / 68 h / Ambient temperature

With sulfuric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm950515e

Reference yield:

: 1025903-77-8
(2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester

: (2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 0.5h;
DOI:10.1021/jm950515e

Reference yield:

: 1025903-77-8
(2S,4S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-fluoro-pentanedioic acid di-tert-butyl ester

: N-pteroyl-(αS,γS)-γ-fluoroglutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / 0.5 h / 0 °C

2: 0.1 M piperidine / 3 h / 15 °C

With piperidine; trifluoroacetic acid;
DOI:10.1021/jm950515e