5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine

Base Information

• Chemical Name: 5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine
• CAS No.: 101527-42-8
• Molecular Formula: C₂₆H₃₁FN₂O₅Si
• Molecular Weight: 498.626
• Mol file: 101527-42-8.mol

Synonyms:

Chemical Property of 5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine

Chemical Property:

• Density: 1.26±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine

There total 5 articles about 5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Bromomethyl-1-[(2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (101527-41-7) → 5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine (101527-42-8)

Guidance literature:

With silver fluoride; In acetonitrile; Yield given; Ambient temperature;

DOI:10.1039/c39850001535

Reference yield:

5'-O-tert-butyldiphenylsilylthymidine (101527-40-6) → 5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine (101527-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Irradiation; bromination

2: AgF / acetonitrile / Ambient temperature

With silver fluoride; In acetonitrile;

DOI:10.1039/c39850001535

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5'-O-tert-Butyldiphenylsilyl-2'-deoxy-5-monofluoromethyluridine (101527-42-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: Irradiation; bromination

3: AgF / acetonitrile / Ambient temperature

With pyridine; silver fluoride; In acetonitrile;

DOI:10.1039/c39850001535

upstream raw materials:

5-Bromomethyl-1-[(2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

5'-O-tert-butyldiphenylsilylthymidine

tert-butylchlorodiphenylsilane

thymidine