cyclosarcosyl-L-prolyl>

Base Information

Chemical Name:cyclosarcosyl-L-prolyl>
CAS No.:81017-85-8
Molecular Formula:C₂₁H₂₈N₄O₅S
Molecular Weight:448.543
Hs Code.:

cyclo<glycyl-<S-(p-methoxybenzyl)-L-cysteinyl>sarcosyl-L-prolyl>

Synonyms:

Suppliers and Price of cyclosarcosyl-L-prolyl>

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclosarcosyl-L-prolyl>

Chemical Property:

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Technology Process of cyclosarcosyl-L-prolyl>

There total 7 articles about cyclosarcosyl-L-prolyl> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80957-29-5
N-(t-butoxycarbonyl)sarcosyl-L-proline methyl ester

: 81017-85-8
cyclosarcosyl-L-prolyl>

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / HCl / ethyl acetate / 1 h / Ambient temperature

2: 84 percent / DCC / CHCl₃ / a) -5 deg C, 5 h, b) RT, overnight

3: 100 percent / HCl / ethyl acetate / 1 h / Ambient temperature

4: 73 percent / DCC / CHCl₃ / a) -5 deg C, 5 h, b) RT, overnight

5: 89 percent / NaOH / methanol / 1.5 h

6: 92.8 percent / DCC / CHCl₃ / a) 0 deg C, 20 h, b) 5 deg C, 5 h

7: 3.5 M HCl / ethyl acetate / 0.83 h / 0 °C

8: 1.) glacial acetic acid, pyridine, 2.) ion-exchange resins / 1.) DMF, a) 30 deg C, overnight, b) 60 deg C, 3 h, 2.) H₂O, CH₃OH

With pyridine; hydrogenchloride; sodium hydroxide; ion-exchange resins; acetic acid; dicyclohexyl-carbodiimide; In methanol; chloroform; ethyl acetate;
DOI:10.1246/bcsj.55.3808

Reference yield:

: sarcosyl-L-proline methyl ester hydrochloride

: 81017-85-8
cyclosarcosyl-L-prolyl>

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / DCC / CHCl₃ / a) -5 deg C, 5 h, b) RT, overnight

2: 100 percent / HCl / ethyl acetate / 1 h / Ambient temperature

3: 73 percent / DCC / CHCl₃ / a) -5 deg C, 5 h, b) RT, overnight

4: 89 percent / NaOH / methanol / 1.5 h

5: 92.8 percent / DCC / CHCl₃ / a) 0 deg C, 20 h, b) 5 deg C, 5 h

6: 3.5 M HCl / ethyl acetate / 0.83 h / 0 °C

7: 1.) glacial acetic acid, pyridine, 2.) ion-exchange resins / 1.) DMF, a) 30 deg C, overnight, b) 60 deg C, 3 h, 2.) H₂O, CH₃OH

With pyridine; hydrogenchloride; sodium hydroxide; ion-exchange resins; acetic acid; dicyclohexyl-carbodiimide; In methanol; chloroform; ethyl acetate;
DOI:10.1246/bcsj.55.3808

Reference yield:

: 80957-31-9
N-(t-butoxycarbonyl)sarcosyl-L-proline methyl ester

: 81017-85-8
cyclosarcosyl-L-prolyl>

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / HCl / ethyl acetate / 1 h / Ambient temperature

2: 73 percent / DCC / CHCl₃ / a) -5 deg C, 5 h, b) RT, overnight

3: 89 percent / NaOH / methanol / 1.5 h

4: 92.8 percent / DCC / CHCl₃ / a) 0 deg C, 20 h, b) 5 deg C, 5 h

5: 3.5 M HCl / ethyl acetate / 0.83 h / 0 °C

6: 1.) glacial acetic acid, pyridine, 2.) ion-exchange resins / 1.) DMF, a) 30 deg C, overnight, b) 60 deg C, 3 h, 2.) H₂O, CH₃OH

With pyridine; hydrogenchloride; sodium hydroxide; ion-exchange resins; acetic acid; dicyclohexyl-carbodiimide; In methanol; chloroform; ethyl acetate;
DOI:10.1246/bcsj.55.3808