Technology Process of ethyl 2--3,3-difluoro-5-hexenoate
There total 6 articles about ethyl 2--3,3-difluoro-5-hexenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: benzene / 0.5 h / Ambient temperature
2: SOCl2 / benzene; pyridine / 0.5 h / 0 °C
3: Zn, CuI / dimethylformamide / exothermic reaction
4: benzene / 1 h / Heating
5: 90 percent / ethanol / 48 h / 40 °C
6: 1.) Zn, HCO2H, 2.) KHCO3 / 1.) H2O, 25 deg C, overnight, 2.) ethyl acetate, 0 deg C, 30 min
With
copper(l) iodide; formic acid; thionyl chloride; potassium hydrogencarbonate; zinc;
In
pyridine; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00125a013
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / ethanol / 48 h / 40 °C
2: 1.) Zn, HCO2H, 2.) KHCO3 / 1.) H2O, 25 deg C, overnight, 2.) ethyl acetate, 0 deg C, 30 min
With
formic acid; potassium hydrogencarbonate; zinc;
In
ethanol;
DOI:10.1021/jo00125a013
- Guidance literature:
-
Multi-step reaction with 3 steps
1: benzene / 1 h / Heating
2: 90 percent / ethanol / 48 h / 40 °C
3: 1.) Zn, HCO2H, 2.) KHCO3 / 1.) H2O, 25 deg C, overnight, 2.) ethyl acetate, 0 deg C, 30 min
With
formic acid; potassium hydrogencarbonate; zinc;
In
ethanol; benzene;
DOI:10.1021/jo00125a013
