4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester

Base Information

Chemical Name:4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester
CAS No.:628717-36-2
Molecular Formula:C₄₃H₄₇BrN₂O₁₁S
Molecular Weight:879.823
Hs Code.:

4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester

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Chemical Property of 4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester

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Technology Process of 4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester

There total 10 articles about 4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 628717-30-6
(Z)-1-isopropyloxycarbonyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

: 628717-36-2
4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1248/cpb.51.821

Reference yield:

: 310903-92-5
(Z)-1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 628717-36-2
4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / H₂ / Rh/C / methanol / 1 h / 760 Torr

2.1: 76.6 percent / pyridine; DMAP / 1 h / 25 °C

3.1: 78 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 4 h / 25 °C

4.1: NaH / dimethylformamide / 0.5 h / 0 °C

4.2: 87.9 percent / dimethylformamide / 24 h / 25 °C

5.1: 66.2 percent / K₂CO₃ / methanol / 2 h / 25 °C

6.1: 98.9 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 2 h / 25 °C

7.1: 45.0 mg / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 1 h / 0 °C

With pyridine; dmap; lithium tri(t-butoxy)aluminum hydride; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; triethylamine; Rh on carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.51.821

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 628717-36-2
4-Benzyl-2-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91.2 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2.1: 78 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 4 h / 25 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 87.9 percent / dimethylformamide / 24 h / 25 °C

4.1: 66.2 percent / K₂CO₃ / methanol / 2 h / 25 °C

5.1: 98.9 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 2 h / 25 °C

6.1: 45.0 mg / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 1 h / 0 °C

With dmap; lithium tri(t-butoxy)aluminum hydride; potassium tert-butylate; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.51.821