{4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester

Base Information

• Chemical Name: {4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester
• CAS No.: 618109-10-7
• Molecular Formula: C₆₁H₁₀₈N₈O₁₃
• Molecular Weight: 1161.57
• Mol file: 618109-10-7.mol

Synonyms:

Chemical Property of {4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester

There total 2 articles about {4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → {4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester (618109-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃

2: Cs₂CO₃

With sodium hydrogencarbonate; caesium carbonate;

DOI:10.1039/b303012a

Reference yield:

1,4,7,10-tetraazacyclododecan (294-90-6) → {4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester (618109-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃

2: Cs₂CO₃

With sodium hydrogencarbonate; caesium carbonate;

DOI:10.1039/b303012a

Reference yield:

trifluoroacetic acid (76-05-1) + {4,7-bis-tert-butoxycarbonylmethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10tetraaza-cyclododec-1-yl}-acetic acid tert-butyl ester (618109-10-7) → {4,7-Bis-carboxymethyl-10-[2-hydroxy-5-methyl-3-(4,7,10-tris-carboxymethyl-1,4,7,10-tetraaza-cyclododec-1-ylmethyl)-benzyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-acetic acid; compound with trifluoro-acetic acid

Guidance literature:

DOI:10.1039/b303012a

upstream raw materials:

bromoacetic acid tert-butyl ester

1,4,7,10-tetraazacyclododecan