MDL 201012

Base Information

Chemical Name:MDL 201012
CAS No.:136722-45-7
Molecular Formula:C₁₉H₂₅NO₂
Molecular Weight:299.413
Hs Code.:
Mol file:136722-45-7.mol

Synonyms:

Suppliers and Price of MDL 201012

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MDL201012
1mg
$ 90.00

American Custom Chemicals Corporation
MDL-201012 99.00%
10MG
$ 275.10

Total 3 raw suppliers

Chemical Property of MDL 201012

Chemical Property:

Boiling Point:444.8±45.0 °C(Predicted)
PKA:12.23±0.29(Predicted)
Density:1.119±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

MDL201012 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of MDL 201012

There total 14 articles about MDL 201012 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5407-98-7
1-cyclobutyl-1-phenyl-methanone

: 136722-45-7,136722-46-8,136722-47-9
1-cyclobutyl-1-phenyl-1-hydroxy-7-dimethylaminohept-5-yn-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, from -78 deg C to RT, 1 h

2: 1.) LDA / 1.) THF, hexane, -5 deg C, 1 h, 2.) THF, hexane, toluene, from -78 deg C to RT, 1 h

3: 1.) Cu(OAc)2 / 1.) H₂O, dioxane, 60 deg C, 1 h, 2.) H₂O, dioxane, 90 deg C, 3 h

4: aq. HCl

With hydrogenchloride; copper diacetate; lithium diisopropyl amide;
DOI:10.1021/jm00114a016

Reference yield:

: 91909-16-9
1-cyclobutyl-1-hydroxy-1-phenyl-2-propyne

: 136722-45-7,136722-46-8,136722-47-9
1-cyclobutyl-1-phenyl-1-hydroxy-7-dimethylaminohept-5-yn-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Hg(OAc)2, 2.) thioacetamide / 1.) 72 h, 2.) 3 h

2: aq. KOH / methanol / 0.25 h / Heating

3: dimethylformamide / 12 h / 130 °C

4: 1.) LDA / 1.) THF, hexane, -5 deg C, 1 h, 2.) THF, hexane, toluene, from -78 deg C to RT, 1 h

5: 1.) Cu(OAc)2 / 1.) H₂O, dioxane, 60 deg C, 1 h, 2.) H₂O, dioxane, 90 deg C, 3 h

6: aq. HCl

With hydrogenchloride; potassium hydroxide; copper diacetate; mercury(II) diacetate; thioacetamide; lithium diisopropyl amide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00114a016

Reference yield:

: 135134-16-6
1-cyclobutyl-1-hydroxy-1-phenyl-2-propanone

: 136722-45-7,136722-46-8,136722-47-9
1-cyclobutyl-1-phenyl-1-hydroxy-7-dimethylaminohept-5-yn-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylformamide / 12 h / 130 °C

2: 1.) LDA / 1.) THF, hexane, -5 deg C, 1 h, 2.) THF, hexane, toluene, from -78 deg C to RT, 1 h

3: 1.) Cu(OAc)2 / 1.) H₂O, dioxane, 60 deg C, 1 h, 2.) H₂O, dioxane, 90 deg C, 3 h

4: aq. HCl

With hydrogenchloride; copper diacetate; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00114a016