p38 MAPK-IN-1

Base Information

• Chemical Name: p38 MAPK-IN-1
• CAS No.: 1006378-90-0
• Molecular Formula: C₂₁H₁₄F₂N₂O
• Molecular Weight: 348.352
• Hs Code.: 2933998090
• Mol file: 1006378-90-0.mol

Synonyms:

Chemical Property of p38 MAPK-IN-1

Chemical Property:

• Boiling Point: 527.0±50.0 °C(Predicted)
• PKA: 0.26±0.40(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

p38MAPK-IN-1 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p38 MAPK-IN-1

There total 1 articles about p38 MAPK-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

[3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone (947410-84-6) + acetaldehyde (75-07-0,9002-91-9) → 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-1,7-naphthyridine 7-oxide (1006378-90-0)

Guidance literature:

[3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone; acetaldehyde; With acetic acid; at 110 ℃; for 18h; Microwave irradiation;

With sodium hydroxide; water; pH=6 - 7;

upstream raw materials:

[3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone

acetaldehyde

Refernces

• 1、 -. "1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS". Page/Page column 68. . Retrieved 2008/06/13.