(2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran

Base Information

Chemical Name:(2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran
CAS No.:1268706-27-9
Molecular Formula:C₁₉H₂₀O₂
Molecular Weight:280.367
Hs Code.:

Synonyms:

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Chemical Property of (2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran

Chemical Property:

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Technology Process of (2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran

There total 5 articles about (2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426659-11-1
C₁₆H₁₄BrFO₂

: 1268706-27-9
(2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: C₆₇H₇₀Cl₂N₂O₆Ru; hydrogen; potassium tert-butylate / isopropyl alcohol / 2325.23 Torr

2: potassium tert-butylate / 1,4-dioxane / 100 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / toluene; water / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; C₆₇H₇₀Cl₂N₂O₆Ru; potassium tert-butylate; hydrogen; potassium carbonate; In 1,4-dioxane; water; isopropyl alcohol; toluene; 3: |Suzuki Coupling;
DOI:10.1055/s-0032-1317704

Reference yield:

: 1426659-07-5
C₁₅H₁₂BrFO₂

: 1268706-27-9
(2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide

2: C₆₇H₇₀Cl₂N₂O₆Ru; hydrogen; potassium tert-butylate / isopropyl alcohol / 2325.23 Torr

3: potassium tert-butylate / 1,4-dioxane / 100 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / toluene; water / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; C₆₇H₇₀Cl₂N₂O₆Ru; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 4: |Suzuki Coupling;
DOI:10.1055/s-0032-1317704

Reference yield:

: 883514-21-4
2-(5-bromo-2-fluoro-phenyl)acetic acid

: 1268706-27-9
(2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane

2: aluminum (III) chloride / dichloromethane / -5 - 23 °C

3: sodium hydride / N,N-dimethyl-formamide

4: C₆₇H₇₀Cl₂N₂O₆Ru; hydrogen; potassium tert-butylate / isopropyl alcohol / 2325.23 Torr

5: potassium tert-butylate / 1,4-dioxane / 100 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / toluene; water / 80 °C

With aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; C₆₇H₇₀Cl₂N₂O₆Ru; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 2: |Friedel-Crafts Acylation / 6: |Suzuki Coupling;
DOI:10.1055/s-0032-1317704