3-methyl-2-(3-p-tolyl-butyl)-oxetane

Base Information

Chemical Name:3-methyl-2-(3-p-tolyl-butyl)-oxetane
CAS No.:937207-98-2
Molecular Formula:C₁₅H₂₂O
Molecular Weight:218.339
Hs Code.:

3-methyl-2-(3-<i>p</i>-tolyl-butyl)-oxetane

Synonyms:

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Chemical Property of 3-methyl-2-(3-p-tolyl-butyl)-oxetane

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Technology Process of 3-methyl-2-(3-p-tolyl-butyl)-oxetane

There total 13 articles about 3-methyl-2-(3-p-tolyl-butyl)-oxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: toluene-4-sulfonic acid 3-hydroxy-2-methyl-6-p-tolyl-heptyl ester

: 937207-98-2
3-methyl-2-(3-p-tolyl-butyl)-oxetane

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1016/j.tetlet.2007.02.103

Reference yield:

: 937207-94-8
4-benzyl-3-(2-p-tolyl-propionyl)-oxazolidin-2-one

: 937207-98-2
3-methyl-2-(3-p-tolyl-butyl)-oxetane

Guidance literature:: Multi-step reaction with 11 steps

1: 95 percent / NaBH₄ / tetrahydrofuran; H₂O / 12 h / 20 °C

2: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 °C

3: 1.77 g / CH₂Cl₂ / 12 h / 20 °C

4: 99 percent / H₂ / Pd/C / ethyl acetate / 3 h

5: 78 percent / DIBAL-H / CH₂Cl₂; toluene / 0.5 h / -78 °C

6: 93 percent / TiCl₄; N,N-diisopropylethylamine / CH₂Cl₂ / 1.5 h / -78 °C

7: 97 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

8: 78 percent / NaBH₄ / methanol; tetrahydrofuran / 12 h / 20 °C

9: 97 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

10: PTSA / methanol / 6 h / 20 °C

11: 682 mg / NaH / tetrahydrofuran / 6 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; titanium tetrachloride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; 2: Swern oxidation / 3: Wittig olefination / 6: Crimmins protocol;
DOI:10.1016/j.tetlet.2007.02.103

Reference yield:

: 622-47-9
4-tolylacetic acid

: 937207-98-2
3-methyl-2-(3-p-tolyl-butyl)-oxetane

Guidance literature:: Multi-step reaction with 13 steps

1.1: 82 percent / Et₃N; pivaloyl chloride / tetrahydrofuran / -20 - 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 56 percent / HMPA / tetrahydrofuran / 2 h / -30 °C

3.1: 95 percent / NaBH₄ / tetrahydrofuran; H₂O / 12 h / 20 °C

4.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 °C

5.1: 1.77 g / CH₂Cl₂ / 12 h / 20 °C

6.1: 99 percent / H₂ / Pd/C / ethyl acetate / 3 h

7.1: 78 percent / DIBAL-H / CH₂Cl₂; toluene / 0.5 h / -78 °C

8.1: 93 percent / TiCl₄; N,N-diisopropylethylamine / CH₂Cl₂ / 1.5 h / -78 °C

9.1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

10.1: 78 percent / NaBH₄ / methanol; tetrahydrofuran / 12 h / 20 °C

11.1: 97 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

12.1: PTSA / methanol / 6 h / 20 °C

13.1: 682 mg / NaH / tetrahydrofuran / 6 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; pivaloyl chloride; titanium tetrachloride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; 4.1: Swern oxidation / 5.1: Wittig olefination / 8.1: Crimmins protocol;
DOI:10.1016/j.tetlet.2007.02.103