3-chloro-2-(4-methoxyphenyl)-N-methylindole

Base Information

• Chemical Name: 3-chloro-2-(4-methoxyphenyl)-N-methylindole
• CAS No.: 1207426-79-6
• Molecular Formula: C₁₆H₁₄ClNO
• Molecular Weight: 271.746
• Mol file: 1207426-79-6.mol

Synonyms:

Chemical Property of 3-chloro-2-(4-methoxyphenyl)-N-methylindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-chloro-2-(4-methoxyphenyl)-N-methylindole

There total 2 articles about 3-chloro-2-(4-methoxyphenyl)-N-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

para-iodoanisole (696-62-8) + 3-chloro-1-methyl-1H-indole (124589-41-9) → 3-chloro-2-(4-methoxyphenyl)-N-methylindole (1207426-79-6)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo902515z

Reference yield: 10.0%

1-bromo-4-methoxy-benzene (104-92-7) + 3-chloro-1-methyl-1H-indole (124589-41-9) → 3-chloro-2-(4-methoxyphenyl)-N-methylindole (1207426-79-6)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo902515z

upstream raw materials:

1-bromo-4-methoxy-benzene

3-chloro-1-methyl-1H-indole

para-iodoanisole

Refernces