5′-O-(4,4′-dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁴-phenoxyacetylcytidine 3′-N,N-dimethyl-S-(2,4-dichlorobenzyl)phosphorothioamidite

Base Information

• Chemical Name: 5′-O-(4,4′-dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁴-phenoxyacetylcytidine 3′-N,N-dimethyl-S-(2,4-dichlorobenzyl)phosphorothioamidite
• CAS No.: 1404222-89-4
• Molecular Formula: C₅₃H₆₁Cl₂N₄O₉PSSi
• Molecular Weight: 1060.12

Synonyms:

Chemical Property of 5′-O-(4,4′-dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁴-phenoxyacetylcytidine 3′-N,N-dimethyl-S-(2,4-dichlorobenzyl)phosphorothioamidite

Chemical Property:

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Safty Information:

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Technology Process of 5′-O-(4,4′-dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁴-phenoxyacetylcytidine 3′-N,N-dimethyl-S-(2,4-dichlorobenzyl)phosphorothioamidite

There total 2 articles about 5′-O-(4,4′-dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁴-phenoxyacetylcytidine 3′-N,N-dimethyl-S-(2,4-dichlorobenzyl)phosphorothioamidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N4-phenoxyacetylcytidine (1003310-24-4) → 5′-O-(4,4′-dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N4-phenoxyacetylcytidine 3′-N,N-dimethyl-S-(2,4-dichlorobenzyl)phosphorothioamidite (1404222-89-4,1404222-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

2: acetonitrile / 0.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1021/jo301834p

Reference yield:

C48H62N5O9PSi + 2,4-dichlorobenzyl mercaptan (59293-67-3) → 5′-O-(4,4′-dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N4-phenoxyacetylcytidine 3′-N,N-dimethyl-S-(2,4-dichlorobenzyl)phosphorothioamidite (1404222-89-4,1404222-90-7)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/jo301834p

upstream raw materials:

2,4-dichlorobenzyl mercaptan

5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N4-phenoxyacetylcytidine

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