(2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid

Base Information

Chemical Name:(2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid
CAS No.:1002128-53-1
Molecular Formula:C₂₀H₁₇F₃O₃
Molecular Weight:362.348
Hs Code.:

Synonyms:

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Chemical Property of (2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid

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Technology Process of (2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid

There total 4 articles about (2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₁F₃O₃

: 1002128-53-1
(2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid

Guidance literature:: C₂₂H₂₁F₃O₃; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In water; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm300101n

Reference yield:

: 1002127-15-2
ethyl (E)-5,5-dibromo-2,4-pentadienoate

: 1002128-53-1
(2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 6 h / 70 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate / 1,4-dioxane; water / 4.5 h / 70 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 4 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1.1: Suzuki coupling / 2.1: Suzuki coupling;
DOI:10.1021/jm300101n

Reference yield:

: 1002127-25-4
ethyl (2E,4Z)-5-bromo-5-(4-trifluoromethylphenyl)-2,4-pentadienoate

: 1002128-53-1
(2E,4Z)-5-(4-Ethoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate / 1,4-dioxane; water / 4.5 h / 70 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 4 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1.1: Suzuki coupling;
DOI:10.1021/jm300101n