Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe

Base Information

• Chemical Name: Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe
• CAS No.: 1448070-15-2
• Molecular Formula: C₅₄H₅₈N₆O₁₃
• Molecular Weight: 999.087
• Mol file: 1448070-15-2.mol

Synonyms:

Chemical Property of Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe

There total 10 articles about Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) + H-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe → Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe (1448070-15-2)

Guidance literature:

BOC-L-aspartic acid 4-benzyl ester; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃;

H-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe; With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1002/chem.201300796

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe (1448070-15-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 24 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2.2: 0 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

3.2: 48 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

4.2: 0 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

5.2: 48 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

6.2: 0 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

7.2: 48 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201300796

Reference yield:

4-benzyl 1-methyl N-(tert-butoxycarbonyl)-L-aspartate (80963-12-8) → Boc-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe (1448070-15-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

1.2: 0 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

2.2: 48 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

3.2: 0 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

4.2: 48 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

5.2: 0 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

6.2: 48 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/chem.201300796

upstream raw materials:

BOC-L-aspartic acid 4-benzyl ester

4-benzyl 1-methyl N-(tert-butoxycarbonyl)-L-aspartate

Boc-Phe(p-NO₂)-OH

Asp-α-OMe-β-OBzl

Downstream raw materials:

H-Asp(OBzl)-Asp(OBzl)-azoPhe-Asp(OBzl)-OMe