(1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Base Information

Chemical Name:(1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid
CAS No.:1412975-41-7
Molecular Formula:C₂₄H₂₇FN₂O₆S
Molecular Weight:490.553
Hs Code.:

(1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Chemical Property of (1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Technology Process of (1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

There total 13 articles about (1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (1aRS,7bSR)-5-amino-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1412975-41-7
(1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: chiral SFC separation using a Lux C-3 column / Resolution of racemate

2.1: dichloromethane / 120 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.2: 1 h / 20 °C

4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 0.67 h / 130 °C / Microwave irradiation

With lithium hydroxide monohydrate; water; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

Reference yield:

: methyl (1aRS,7bSR)-5-(2,2-dimethylpropionylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1412975-41-7
(1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / methanol / 60 h / Reflux; Inert atmosphere

2.1: chiral SFC separation using a Lux C-3 column / Resolution of racemate

3.1: dichloromethane / 120 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 0.67 h / 130 °C / Microwave irradiation

With lithium hydroxide monohydrate; sulfuric acid; water; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1412976-22-7
methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1412975-41-7
(1aR,7bS)-5-[2-((S)-1-ethylpyrrolidin-3-yloxymethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 120 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 0.67 h / 130 °C / Microwave irradiation

With lithium hydroxide monohydrate; water; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;