TPT-260 Dihydrochloride

Base Information

• Chemical Name: TPT-260 Dihydrochloride
• CAS No.: 2076-91-7
• Molecular Formula: C8H12 N4 S3 . 2 Cl H
• Molecular Weight: 333.32456
• European Community (EC) Number: 808-974-6
• Mol file: 2076-91-7.mol

Synonyms:TPT-260 Dihydrochloride;2076-91-7;TPT-260 (Dihydrochloride);thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride;NSC 55712;Tpt-260 2HCl;[5-(carbamimidoylsulfanylmethyl)thiophen-2-yl]methyl carbamimidothioate;dihydrochloride;NSC55712;TPT 260;TPT-260Dihydrochloride;TPT 260 Dihydrochloride;TPU-260 Dihydrochloride;TPU260 2HCl;SCHEMBL2809386;EX-A377;BCP09401;CAA07691;HY-13769A;MFCD25976641;AKOS027252590;TPT-260 2HCl(NSC55712);AC-35965;AS-16699;thiophene-2,5-diylbis(methylene) dicarbamimidothioate 2hcl;Carbamimidothioic acid, C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)

Chemical Property of TPT-260 Dihydrochloride

Chemical Property:

• Melting Point: 210℃ (Decomposition)
• Boiling Point: 436.9oC at 760 mmHg
• Flash Point: 218oC
• PSA: 178.58000
• Density: 1.59g/cm3
• LogP: 4.40350
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 331.9757654
• Heavy Atom Count: 17
• Complexity: 222

Purity/Quality:

97% ^*data from raw suppliers

TPT-2602HCl(NSC55712) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC(=C1)CSC(=N)N)CSC(=N)N.Cl.Cl
• Uses: Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]