4-nitromethyl-2-oxochroman

Base Information

• Chemical Name: 4-nitromethyl-2-oxochroman
• CAS No.: 126814-35-5
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.186
• Mol file: 126814-35-5.mol

Synonyms:

Chemical Property of 4-nitromethyl-2-oxochroman

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitromethyl-2-oxochroman

There total 4 articles about 4-nitromethyl-2-oxochroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(nitromethyl)chroman-2-ol → 4-nitromethyl-2-oxochroman (126814-35-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 30h;

DOI:10.1021/jo0260185

Reference yield: 47.0%

ethyl 2-ethoxycarbonyl-3-(2-hydroxyphenyl)-4-nitrobutyrate (126814-18-4) → 4-nitromethyl-2-oxochroman (126814-35-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 2h; Heating;

Reference yield:

methyl 2-oxo-2H-chromene-3-carboxylate (21259-42-7) → 4-nitromethyl-2-oxochroman (126814-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KF / Ambient temperature

2: 47 percent / p-TsOH / toluene / 2 h / Heating

With potassium fluoride; toluene-4-sulfonic acid; In toluene;

upstream raw materials:

ethyl 2-ethoxycarbonyl-3-(2-hydroxyphenyl)-4-nitrobutyrate

methyl 2-oxo-2H-chromene-3-carboxylate

2-Oxo-2H-1-benzopyran-3-carboxylic acid phenyl ester

Refernces

• 1、 Bojilova, A.,Kostadinova, T.,Ivanov, C.. "INTERACTION OF NITROMETHANE WITH ESTERS AND AMIDES OF 2-OXO-2H-1-BENZOPYRANE-3-CARBOXYLIC ACID". . p. 2963 - 2976. Retrieved 2007/10/02.