11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

Base Information

Chemical Name:11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester
CAS No.:932406-88-7
Molecular Formula:C₆₃H₉₄O₁₂Si
Molecular Weight:1071.52
Hs Code.:

11-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

Synonyms:

Suppliers and Price of 11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

There total 24 articles about 11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,4-dimethyl-hept-2-ene-1,5-diol

: 932406-88-7
11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: imidazole

2: 96 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

3: 86 percent / TiCl₄; DIPEA / CH₂Cl₂ / -78 °C

4: 96 percent / diisopropyl azodicarboxylate; PBu₃ / tetrahydrofuran; toluene / 6 h / -30 °C

5: AcOH; H₂O / tetrahydrofuran

6: 98 percent / MnO₂ / CH₂Cl₂ / 2 h / 20 °C

7: 96 percent / NaClO₂; aq. NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 16 h / 20 °C

8: 86 percent / diisopropyl azodicarboxylate; PPh₃ / toluene / 12 h / 20 °C

9: AcOH; H₂O / tetrahydrofuran

10: Dess-Martin periodinane

11: aq. NaClO₂; NaH₂PO₄

With 1H-imidazole; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tributylphosphine; di-isopropyl azodicarboxylate; water; titanium tetrachloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; 2: Dess-Martin oxidation / 4: Mitsunobu dehydration / 8: Mitsunobu esterification / 10: Dess-Martin oxidation;
DOI:10.1021/ol0630191

Reference yield:

: 773896-71-2
2-allyloxy-5-hydroxymethyl-tetrahydro-furan-3,4-diol

: 932406-88-7
11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH

2.1: PdCl₂; O₂; H₂O / CHCl₃

2.2: NaBH₄

3.1: 95 percent / Et₃N / CH₂Cl₂ / 20 h / 0 °C

4.1: 86 percent / diisopropyl azodicarboxylate; PPh₃ / toluene / 12 h / 20 °C

5.1: AcOH; H₂O / tetrahydrofuran

6.1: Dess-Martin periodinane

7.1: aq. NaClO₂; NaH₂PO₄

With sodium chlorite; sodium dihydrogenphosphate; di-isopropyl azodicarboxylate; water; oxygen; sodium hydride; Dess-Martin periodane; acetic acid; triethylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; dichloromethane; chloroform; toluene; 4.1: Mitsunobu esterification / 6.1: Dess-Martin oxidation;
DOI:10.1021/ol0630191

Reference yield:

: 932406-79-6
7-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethyl-hept-5-en-3-one

: 932406-88-7
11-(tert-butyl-dimethyl-silanyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid 3-carboxy-2,3-bis-(4-methoxy-benzyloxy)-1-(4-methoxy-benzyloxymethyl)-propyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / TiCl₄; DIPEA / CH₂Cl₂ / -78 °C

2: 96 percent / diisopropyl azodicarboxylate; PBu₃ / tetrahydrofuran; toluene / 6 h / -30 °C

3: AcOH; H₂O / tetrahydrofuran

4: 98 percent / MnO₂ / CH₂Cl₂ / 2 h / 20 °C

5: 96 percent / NaClO₂; aq. NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 16 h / 20 °C

6: 86 percent / diisopropyl azodicarboxylate; PPh₃ / toluene / 12 h / 20 °C

7: AcOH; H₂O / tetrahydrofuran

8: Dess-Martin periodinane

9: aq. NaClO₂; NaH₂PO₄

With manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tributylphosphine; di-isopropyl azodicarboxylate; water; titanium tetrachloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; 2: Mitsunobu dehydration / 6: Mitsunobu esterification / 8: Dess-Martin oxidation;
DOI:10.1021/ol0630191