C₂₂H₂₇FN₆O₂

Base Information

Chemical Name:C₂₂H₂₇FN₆O₂
CAS No.:1227917-65-8
Molecular Formula:C₂₂H₂₇FN₆O₂
Molecular Weight:426.494
Hs Code.:

C<sub>22</sub>H<sub>27</sub>FN<sub>6</sub>O<sub>2</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₂H₂₇FN₆O₂

Chemical Property:

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Technology Process of C₂₂H₂₇FN₆O₂

There total 7 articles about C₂₂H₂₇FN₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 1227917-64-7
C₁₅H₂₄ClN₅O₂

: 1227917-65-8
C₂₂H₂₇FN₆O₂

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 95 ℃;
DOI:10.1021/jm101527u

Reference yield:

: 5470-70-2
Methyl 6-methylnicotinate

: 1227917-65-8
C₂₂H₂₇FN₆O₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol; water / 4.5 h / 20 °C / 3102.97 Torr

1.2: 15 - 25 °C

2.1: ChiralPak IC / carbon dioxide; isopropyl alcohol / Resolution of racemate; Supercritical conditions

3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

4.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 20 °C

4.2: 20 h / 100 °C

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C / 2585.81 Torr

6.1: methanol; ethanol / 50 - 100 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 95 °C

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; carbon dioxide; water; ethyl acetate; isopropyl alcohol; tert-butyl alcohol; 7.1: Suzuki coupling;
DOI:10.1021/jm101527u

Reference yield:

: 1227917-62-5
(3R,6S)-3-methyl 1-(phenylmethyl) 6-methyl-1,3-piperidinedicarboxylate

: 1227917-65-8
C₂₂H₂₇FN₆O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 20 °C

2.2: 20 h / 100 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C / 2585.81 Torr

4.1: methanol; ethanol / 50 - 100 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; ethyl acetate; tert-butyl alcohol; 5.1: Suzuki coupling;
DOI:10.1021/jm101527u