phenyl 3-quinolylmethyl ketone oxime

Base Information

• Chemical Name: phenyl 3-quinolylmethyl ketone oxime
• CAS No.: 80999-02-6
• Molecular Formula: C₁₇H₁₄N₂O
• Molecular Weight: 262.311
• Mol file: 80999-02-6.mol

Synonyms:

Chemical Property of phenyl 3-quinolylmethyl ketone oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyl 3-quinolylmethyl ketone oxime

There total 2 articles about phenyl 3-quinolylmethyl ketone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-phenylethynyl)quinoline (70437-03-5) → phenyl 3-quinolylmethyl ketone oxime (80999-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / H₂O / HgSO₄, conc. H₂SO₄ / acetone / 18 h

2: 1.) KOH, HONH₂*HCl / 1.) MeOH, water, 2.) MeOH, water, 21 h, reflux

With potassium hydroxide; hydroxylamine hydrochloride; water; sulfuric acid; mercury(II) sulfate; In acetone;

DOI:10.1248/cpb.29.3554

Reference yield:

1-phenyl-2-(quinolin-3-yl)ethan-1-one (74212-52-5) → phenyl 3-quinolylmethyl ketone oxime (80999-02-6)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; Yield given. Multistep reaction; 1.) MeOH, water, 2.) MeOH, water, 21 h, reflux;

DOI:10.1248/cpb.29.3554

Reference yield: 55.0%

phenyl 3-quinolylmethyl ketone oxime (80999-02-6) → N-phenyl-3-quinolylacetamide (80999-03-7)

Guidance literature:

With phosphorus pentachloride; In diethyl ether; for 20h; Ambient temperature; adding 0-5 deg C;

DOI:10.1248/cpb.29.3554

upstream raw materials:

1-phenyl-2-(quinolin-3-yl)ethan-1-one

3-(2-phenylethynyl)quinoline

Downstream raw materials:

N-phenyl-3-quinolylacetamide

2-(quinolin-3-yl)acetic acid

Refernces