(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone

Base Information

Chemical Name:(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone
CAS No.:1319194-26-7
Molecular Formula:C₂₅H₂₇N₃O₃
Molecular Weight:417.508
Hs Code.:

Synonyms:

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Chemical Property of (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone

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Technology Process of (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone

There total 6 articles about (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5807-02-3
4-morpholinoacetonitrile

: 1319194-26-7
(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / dimethyl sulfoxide / 4 h / 80 °C

1.2: 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 85 °C / Inert atmosphere

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.2 h / 140 °C / microwave irradiation

With potassium phosphate; water; potassium acetate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 1319196-51-4
6-bromo-3-morpholinoquinolin-2-amine

: 1319194-26-7
(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 85 °C / Inert atmosphere

2: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.2 h / 140 °C / microwave irradiation

With potassium phosphate; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water;

Reference yield:

: 1319196-68-3
(2-bromo-3-methylphenyl)(morpholino)methanone

: 1319194-26-7
(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(tetrahydrofuran-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; pentanes / 1.17 h / -78 - 0 °C / Inert atmosphere

1.2: -78 - 0 °C

2.1: hydrogen / platinum on carbon / ethyl acetate; diethyl ether / Inert atmosphere

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.2 h / 140 °C / microwave irradiation

With potassium phosphate; n-butyllithium; hydrogen; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; platinum on carbon; XPhos; In tetrahydrofuran; 1,4-dioxane; pentanes; diethyl ether; water; ethyl acetate;