Technology Process of 1-(2-benzyl-1,3-dioxoisoindolin-5-yl)-3-((R)-1-phenyl-ethyl)thiourea
There total 5 articles about 1-(2-benzyl-1,3-dioxoisoindolin-5-yl)-3-((R)-1-phenyl-ethyl)thiourea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
1,4-dioxane;
at 100 ℃;
for 24h;
Inert atmosphere;
DOI:10.1039/c0pp00175a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1.5 h / 140 °C
2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 4 h / 20 °C
3.1: dichloromethane / 0.17 h / 20 °C
3.2: 4 h / 20 °C
4.1: 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
With
5%-palladium/activated carbon; hydrogen; potassium carbonate; potassium iodide;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0pp00175a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 5%-palladium/activated carbon; hydrogen / ethanol / 4 h / 20 °C
2.1: dichloromethane / 0.17 h / 20 °C
2.2: 4 h / 20 °C
3.1: 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
With
5%-palladium/activated carbon; hydrogen;
In
1,4-dioxane; ethanol; dichloromethane;
DOI:10.1039/c0pp00175a
