SAR-020106

Base Information

Chemical Name:SAR-020106
CAS No.:1184843-57-9
Molecular Formula:C₁₉H₁₉ClN₆O
Molecular Weight:382.852
Hs Code.:
Mol file:1184843-57-9.mol

Synonyms:

Suppliers and Price of SAR-020106

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
2.5mg
$ 370.00

Crysdot
SAR-020106 97%
1g
$ 872.00

Crysdot
SAR-020106 97%
100mg
$ 218.00

Crysdot
SAR-020106 97%
250mg
$ 349.00

ChemScene
SAR-020106 98.53%
10mg
$ 320.00

ChemScene
SAR-020106 98.53%
5mg
$ 200.00

ChemScene
SAR-020106 98.53%
50mg
$ 950.00

ChemScene
SAR-020106 98.53%
25mg
$ 600.00

AK Scientific
SAR020106
10mg
$ 625.00

Adipogen Life Sciences
SAR-020106 ≥95%
50 mg
$ 2009.00

Total 13 raw suppliers

Chemical Property of SAR-020106

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile is a potent and selective CHK1 inhibitor. CHK1 is a serine/threonine kinase involved with DNA damage repair and cell cycle arrest.

Technology Process of SAR-020106

There total 3 articles about SAR-020106 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1009608-67-6
8-chloroisoquinolin-3-yl trifluoromethanesulfonate

: 1184843-17-1
(R)-5-amino-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile

: 1184843-57-9
SAR 020106

Guidance literature:: 8-chloroisoquinolin-3-yl trifluoromethanesulfonate; (R)-5-amino-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 130 ℃; for 0.75h; Inert atmosphere; Microwave irradiation;

In methanol; toluene; Inert atmosphere;
DOI:10.1021/jm2007326

Reference yield:

: 53636-15-0,53657-16-2
(R)-1-(dimethylamino)-2-propanol

: 34617-65-7
5-amino-3-chloro-pyrazine-2-carbonitrile

: 1184843-57-9
SAR 020106

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 100 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 0.75 h / 130 °C / Inert atmosphere; Microwave irradiation

2.2: acidic ion exchange column / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; toluene; mineral oil;
DOI:10.1021/jm2007326