pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

Base Information

Chemical Name:pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate
CAS No.:1383570-17-9
Molecular Formula:C₃₉H₅₀N₆O₄S
Molecular Weight:698.93
Hs Code.:

pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

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Chemical Property of pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

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Technology Process of pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

There total 6 articles about pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383570-59-9
tert-butyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate

: 1383570-17-9
pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 16 h

2: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm400288z

Reference yield:

: 1383570-15-7
tert-butyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

: 1383570-17-9
pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm400288z

Reference yield:

: (2R,5R)-1,6-diphenylhexane-2,5-diamine hydrochloride

: 1383570-17-9
pyridin-3-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol / 16 h

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 16 h

3: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm400288z