Technology Process of (3R,4S)-1-tert-butoxycarbonyl-3,4-dihydroxypiperidine
There total 5 articles about (3R,4S)-1-tert-butoxycarbonyl-3,4-dihydroxypiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / sodium azide; tetrabutylammonium iodide / dimethylformamide / 36 h / 80 °C
2: 65 percent / Amberlyst 15 / H2O / 4 h / 20 °C
3: 0.81 g / H2 / palladium on carbon / ethanol / 24 h / 20 °C / 3102.97 Torr
4: 2.53 g / ethanol / 48 h
With
sodium azide; Amberlyst 15; hydrogen; tetra-(n-butyl)ammonium iodide;
palladium on activated charcoal;
In
ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0712143
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 0.81 g / H2 / palladium on carbon / ethanol / 24 h / 20 °C / 3102.97 Torr
2: 2.53 g / ethanol / 48 h
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jo0712143
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 65 percent / Amberlyst 15 / H2O / 4 h / 20 °C
2: 0.81 g / H2 / palladium on carbon / ethanol / 24 h / 20 °C / 3102.97 Torr
3: 2.53 g / ethanol / 48 h
With
Amberlyst 15; hydrogen;
palladium on activated charcoal;
In
ethanol; water;
DOI:10.1021/jo0712143
