C₁₉H₁₆ClN₂O₆S^(1-)*Na⁽¹⁺⁾

Base Information

• Chemical Name: C₁₉H₁₆ClN₂O₆S^(1-)*Na⁽¹⁺⁾
• CAS No.: 644986-06-1
• Molecular Formula: C₁₉H₁₆ClN₂O₆S*Na
• Molecular Weight: 458.855

Synonyms:

Chemical Property of C₁₉H₁₆ClN₂O₆S^(1-)*Na⁽¹⁺⁾

Chemical Property:

Purity/Quality:

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Technology Process of C₁₉H₁₆ClN₂O₆S^(1-)*Na⁽¹⁺⁾

There total 9 articles about C₁₉H₁₆ClN₂O₆S^(1-)*Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-chlorophenoxy)-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine (263391-17-9) → C19H16ClN2O6S(1-)*Na(1+) (644986-06-1)

Guidance literature:

With sulfur trioxide trimethylamine complex; sodium hydroxide; In water; at 50 ℃; for 3h;

DOI:10.1016/j.bmcl.2014.04.052

Reference yield:

2-bromo-pyridin-3-ol (6602-32-0) → C19H16ClN2O6S(1-)*Na(1+) (644986-06-1)

Guidance literature:

Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice; Inert atmosphere

2: potassium carbonate; copper(I) bromide / N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere

3: hydrogen bromide / N,N-dimethyl-formamide; acetic acid / 2 h / 120 °C / Inert atmosphere

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere; Cooling with ice

5: sulfur trioxide trimethylamine complex; sodium hydroxide / water / 3 h / 50 °C

With di-isopropyl azodicarboxylate; hydrogen bromide; sulfur trioxide trimethylamine complex; potassium carbonate; triphenylphosphine; copper(I) bromide; sodium hydroxide; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; 1: |Mitsunobu Displacement / 4: |Mitsunobu Displacement;

DOI:10.1016/j.bmcl.2014.04.052

Reference yield:

2-bromo-3-cyclopentyloxypyridine (263390-53-0) → C19H16ClN2O6S(1-)*Na(1+) (644986-06-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; copper(I) bromide / N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere

2: hydrogen bromide / N,N-dimethyl-formamide; acetic acid / 2 h / 120 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere; Cooling with ice

4: sulfur trioxide trimethylamine complex; sodium hydroxide / water / 3 h / 50 °C

With di-isopropyl azodicarboxylate; hydrogen bromide; sulfur trioxide trimethylamine complex; potassium carbonate; triphenylphosphine; copper(I) bromide; sodium hydroxide; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; 3: |Mitsunobu Displacement;

DOI:10.1016/j.bmcl.2014.04.052

upstream raw materials:

2-bromo-pyridin-3-ol

3-(3-methoxymethoxypyridin-4-yl)-propionic acid ethyl ester

3-(3-methoxymethoxypyridin-4-yl)-1-propanol

2-bromo-3-cyclopentyloxypyridine

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