4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid

Base Information

Chemical Name:4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid
CAS No.:1403326-83-9
Molecular Formula:C₁₅H₁₀F₂O₄
Molecular Weight:292.239
Hs Code.:

Synonyms:

Suppliers and Price of 4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of 4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid

There total 2 articles about 4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403326-80-6
benzyl-3,5-difluoro-4-formylbenzoate

: 1403326-83-9
4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid

Guidance literature:: With sodium chlorite; aminosulfonic acid; In water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1002/cmdc.201200319

Reference yield:

: 455-40-3
3,5-difluorobenzoic acid

: 1403326-83-9
4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h

2.2: 5 h / 20 °C

3.1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 1 h / 20 °C

With sodium chlorite; aminosulfonic acid; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; pentane;
DOI:10.1002/cmdc.201200319

Reference yield:

: 1403326-83-9
4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid

: 1331832-71-3
C₂₄H₂₆F₂O₂

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 1 h / 84 °C

2: triethylamine / toluene / 1.17 h / 20 °C

3: hydrogen; 10% Pd/C / ethyl acetate; ethanol / 48 h / 20 °C

4: thionyl chloride / 1 h / 85 °C

5: aluminum (III) chloride / dichloromethane / 0.33 h / 20 °C / Reflux

6: tetrahydrofuran / 20 °C

7: water; potassium hydroxide / methanol / 1 h / 85 °C

With aluminum (III) chloride; thionyl chloride; 10% Pd/C; water; hydrogen; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1002/cmdc.201200319