2-(1-p-Tolyl-ethyl)-malonsaeure

Base Information

• Chemical Name: 2-(1-p-Tolyl-ethyl)-malonsaeure
• CAS No.: 39027-65-1
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 39027-65-1.mol

Synonyms:

Chemical Property of 2-(1-p-Tolyl-ethyl)-malonsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-p-Tolyl-ethyl)-malonsaeure

There total 4 articles about 2-(1-p-Tolyl-ethyl)-malonsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-(1-(4'-methylphenyl)-ethyl)malonate (39027-56-0) → 2-(1-p-Tolyl-ethyl)-malonsaeure (39027-65-1)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1135/cccc19760633

Reference yield:

CH3C6H4CH(CH3)OH (536-50-5) → 2-(1-p-Tolyl-ethyl)-malonsaeure (39027-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: PBr₃, Py / diethyl ether

2: NaOEt / ethanol

3: aq. KOH / ethanol / Heating

With pyridine; potassium hydroxide; sodium ethanolate; phosphorus tribromide; In diethyl ether; ethanol;

DOI:10.1135/cccc19760633

Reference yield:

1-(1-bromoethyl)-4-methylbenzene (159755-12-1) → 2-(1-p-Tolyl-ethyl)-malonsaeure (39027-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / ethanol

2: aq. KOH / ethanol / Heating

With potassium hydroxide; sodium ethanolate; In ethanol;

DOI:10.1135/cccc19760633

upstream raw materials:

diethyl 2-(1-(4'-methylphenyl)-ethyl)malonate

CH₃C₆H₄CH(CH₃)OH

1-(1-bromoethyl)-4-methylbenzene