3-oxo-14α-andrographolide

Base Information

• Chemical Name: 3-oxo-14α-andrographolide
• CAS No.: 955428-65-6
• Molecular Formula: C₂₀H₂₈O₅
• Molecular Weight: 348.439
• Mol file: 955428-65-6.mol

Synonyms:

Chemical Property of 3-oxo-14α-andrographolide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-oxo-14α-andrographolide

There total 1 articles about 3-oxo-14α-andrographolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

andrographolide (142037-79-4,5508-58-7) → andrographolide + 3-dehydro-14-deoxyandrographolide (4176-99-2) + 12(S),13(S)-12-hydroxyandrographolide (1020673-18-0) + 12(R),13(R)-12-hydroxyandrographolide (1020673-19-1) + 3-oxo-14-deoxy-11,12-didehydroandrographolide + 3-dehydro-14-deoxyandrographolide-19-oic acid (1262950-30-0) + 3-oxo-14α-andrographolide (955428-65-6) + 3-dehydroisoandrographolide (1262950-29-7) + 14-deoxyandrographolide (4176-97-0) + 14-dehydroxy-11,12-didehydroandrographolide

Guidance literature:

With Rhizopus stolonifer ATCC 12939; In methanol; water; at 28 ℃; for 96h; Enzymatic reaction;

DOI:10.1016/j.molcatb.2009.11.002

Reference yield:

3-oxo-14α-andrographolide (955428-65-6) → C25H33NO3

Guidance literature:

Multi-step reaction with 2 steps

1: samarium diiodide; acrylic acid methyl ester / 2,2,2-trifluoroethanol; tetrahydrofuran / 0.42 h / 65 °C

2: C₁₄H₁₅N₃O*C₁₀H₁₅^(1-)*Ir⁽²⁺⁾*Cl^(1-); formic acid / methanol / 65 °C

With formic acid; samarium diiodide; C₁₄H₁₅N₃O*C₁₀H₁₅^(1-)*Ir⁽²⁺⁾*Cl^(1-); acrylic acid methyl ester; In tetrahydrofuran; methanol; 2,2,2-trifluoroethanol;

DOI:10.1038/nchem.2835

upstream raw materials:

andrographolide

Refernces