(E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt

Base Information

Chemical Name:(E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt
CAS No.:1430562-37-0
Molecular Formula:C₂HF₃O₂*C₃₄H₃₃ClFN₉O₃
Molecular Weight:784.17
Hs Code.:

(E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt

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Chemical Property of (E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt

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Technology Process of (E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt

There total 5 articles about (E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.6%

: 1094106-58-7
trans-3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acrylic acid

: 1430115-41-5
tert-butyl 6-isocyano-1H-indazole-1-carboxylate

: 1448178-39-9
C₂₁H₂₈N₂O₃

: 76-05-1
trifluoroacetic acid

: 1430562-37-0
(E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt

Guidance literature:: trans-3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acrylic acid; tert-butyl 6-isocyano-1H-indazole-1-carboxylate; C₂₁H₂₈N₂O₃; In ethanol; for 24h; Reflux;

trifluoroacetic acid; In dichloromethane;

Reference yield:

: 2439-04-5
5-hydroxyisoquinoline

: 1430562-37-0
(E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 14 h / 90 °C

2: ethanol / 24 h / Reflux

With caesium carbonate; sodium iodide; In ethanol; N,N-dimethyl-formamide; 2: |Ugi Condensation;

Reference yield:

: 169457-73-2
tert-butyl 4-(2-bromoethyl)piperidine-1-carboxylate

: 1430562-37-0
(E)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-5-(2-(piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate salt

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 14 h / 90 °C

2: ethanol / 24 h / Reflux

With caesium carbonate; sodium iodide; In ethanol; N,N-dimethyl-formamide; 2: |Ugi Condensation;