Technology Process of 7-[(4-methoxyphenyl)acetyl]-2-[(1R)-5-(2H-1,2,3-triazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane
There total 11 articles about 7-[(4-methoxyphenyl)acetyl]-2-[(1R)-5-(2H-1,2,3-triazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium diisopropyl amide / tetrahydrofuran
2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
3: oxalyl dichloride; triethylamine / dimethyl sulfoxide; dichloromethane
4: acetic acid; sodium cyanoborohydride / methanol / 20 h / 70 °C
5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
With
lithium aluminium tetrahydride; oxalyl dichloride; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.044
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
2: oxalyl dichloride; triethylamine / dimethyl sulfoxide; dichloromethane
3: acetic acid; sodium cyanoborohydride / methanol / 20 h / 70 °C
4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
With
lithium aluminium tetrahydride; oxalyl dichloride; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.044
- Guidance literature:
-
Multi-step reaction with 5 steps
1: borane-THF / tetrahydrofuran / 2.5 h / 0 °C
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 2-methyltetrahydrofuran
3: lithium aluminium tetrahydride / 2-methyltetrahydrofuran / 0.5 h / 0 °C
4: acetic acid; sodium cyanoborohydride / methanol / 20 h / 70 °C
5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
With
lithium aluminium tetrahydride; borane-THF; diphenyl phosphoryl azide; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 2-methyltetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.044
