Technology Process of 4-(3,3-difluoro-5-phenylpent-1-en-2-yl)benzoic acid
There total 5 articles about 4-(3,3-difluoro-5-phenylpent-1-en-2-yl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / -105 - -70 °C / Inert atmosphere
1.2: 1.25 h / -105 - -50 °C / Inert atmosphere
2.1: sulfuric acid / 16 h / Reflux; Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 0 - 20 °C / Inert atmosphere
3.2: 4 h / -78 - 20 °C / Inert atmosphere
4.1: sodium hydroxide / methanol; water / 2 h / Reflux
With
n-butyllithium; sulfuric acid; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water;
2.1: Fischer esterification / 3.1: Whiting reaction / 3.2: Whiting reaction;
DOI:10.1002/anie.201105138
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 16 h / Reflux; Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 0 - 20 °C / Inert atmosphere
2.2: 4 h / -78 - 20 °C / Inert atmosphere
3.1: sodium hydroxide / methanol; water / 2 h / Reflux
With
sulfuric acid; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water;
1.1: Fischer esterification / 2.1: Whiting reaction / 2.2: Whiting reaction;
DOI:10.1002/anie.201105138
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 0 - 20 °C / Inert atmosphere
1.2: 4 h / -78 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol; water / 2 h / Reflux
With
sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water;
1.1: Whiting reaction / 1.2: Whiting reaction;
DOI:10.1002/anie.201105138
