((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

Base Information

Chemical Name:((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid
CAS No.:1026710-79-1
Molecular Formula:C₅₄H₇₀N₈O₁₂
Molecular Weight:1023.2
Hs Code.:

((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

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Chemical Property of ((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

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Technology Process of ((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

There total 14 articles about ((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((S)-4-{2-[(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

: 1026710-79-1
((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1248/cpb.45.1228

Reference yield:

: 76-83-5
trityl chloride

: 1026710-79-1
((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: TEA / CH₂Cl₂

2: 4N aq. HCl / dioxane

3: ethyl((dimethylamino)propyl)carbodiimide hydrochloride, hydroxybenzotriazole, DIPEA / dimethylformamide

4: NaOH / methanol

5: DPPA, TEA / dimethylformamide

6: NaOH / methanol

7: H₂ / Pd/C / methanol

With hydrogenchloride; sodium hydroxide; TEA; diphenyl-phosphinic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1228

Reference yield:

: 202653-55-2
((S)-4-Methoxycarbonylmethyl-3-oxo-piperazin-2-yl)-acetic acid tert-butyl ester

: 1026710-79-1
((S)-4-{2-[(S)-4-{2-[((S)-2-Amino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetyl}-3-tert-butoxycarbonylmethyl-2-oxo-piperazin-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: DPPA, TEA / dimethylformamide

2: NaOH / methanol

3: H₂ / Pd/C / methanol

With sodium hydroxide; TEA; diphenyl-phosphinic acid; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1228