Technology Process of JWH-421
There total 6 articles about JWH-421 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-pentyl-1H-indole;
With
dimethylaluminum chloride;
In
hexane; dichloromethane;
at 0 ℃;
for 0.5h;
Inert atmosphere;
4-iodo-1-naphthoyl chloride;
In
hexane; dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.01.038
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: water; sodium hydroxide / 2 h / Reflux
2.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
3.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
thionyl chloride; water; dimethylaluminum chloride; sodium hydroxide;
In
hexane; dichloromethane;
3.1: Friedel-Crafts reaction / 3.2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2012.01.038
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
1.2: 120 h / 0 - 20 °C / Inert atmosphere
2.1: iodine / 0.67 h / Inert atmosphere; Reflux
3.1: water; sodium hydroxide / 2 h / Reflux
4.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
5.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5.2: 0 - 20 °C / Inert atmosphere
With
aluminum (III) chloride; thionyl chloride; water; iodine; dimethylaluminum chloride; sodium hydroxide;
In
hexane; dichloromethane;
1.1: Friedel-Crafts acylation / 1.2: Friedel-Crafts acylation / 2.1: King reaction / 5.1: Friedel-Crafts reaction / 5.2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2012.01.038
