8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene

Base Information

• Chemical Name: 8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene
• CAS No.: 858456-81-2
• Molecular Formula: C₁₉H₂₀O₂
• Molecular Weight: 280.367
• Mol file: 858456-81-2.mol

Synonyms:

Chemical Property of 8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene

There total 5 articles about 8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-hydroxy-5-methoxy-phenyl)-butyric acid (55953-85-0) → 8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene (858456-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous H₂SO₄

2: pyridine; diethyl ether / Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts unter vermindertem Druck

3: sodium methylate; methanol

With pyridine; methanol; diethyl ether; sulfuric acid; sodium methylate;

DOI:10.1021/ja01626a054

Reference yield:

5-hydroxy-8-methoxy-3,4-dihydronaphthalen-1(2H)-one (51062-77-2) → 8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene (858456-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; diethyl ether / Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts unter vermindertem Druck

2: sodium methylate; methanol

With pyridine; methanol; diethyl ether; sodium methylate;

DOI:10.1021/ja01626a054

Reference yield:

4-(2-Hydroxy-5-methoxyphenyl)-4-oxobutanoic Acid (75501-54-1) → 8-benzyloxy-5-methoxy-4-methyl-1,2-dihydro-naphthalene (858456-81-2)

Guidance literature:

Multi-step reaction with 4 steps

1: copper oxide-chromium oxide; aqueous KOH

2: aqueous H₂SO₄

3: pyridine; diethyl ether / Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts unter vermindertem Druck

4: sodium methylate; methanol

With pyridine; methanol; potassium hydroxide; diethyl ether; copper oxide-chromium oxide; sulfuric acid; sodium methylate;

DOI:10.1021/ja01626a054

upstream raw materials:

4-Methoxy-5-methyl-7,8-dihydro-[1]naphthol

benzyl bromide

4-(2-hydroxy-5-methoxy-phenyl)-butyric acid

5-hydroxy-8-methoxy-3,4-dihydronaphthalen-1(2H)-one