C₃₃H₄₁F₂NO₁₈

Base Information

• Chemical Name: C₃₃H₄₁F₂NO₁₈
• CAS No.: 1415238-60-6
• Molecular Formula: C₃₃H₄₁F₂NO₁₈
• Molecular Weight: 777.681
• Mol file: 1415238-60-6.mol

Synonyms:

Chemical Property of C₃₃H₄₁F₂NO₁₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₁F₂NO₁₈

There total 1 articles about C₃₃H₄₁F₂NO₁₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-formyl-4-nitro 2,3,4,6,2′ ,3′,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose (1415238-58-2) → C33H41F2NO18 (1415238-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / Inert atmosphere

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; In dichloromethane; ethyl acetate;

DOI:10.1021/ja309790w

Reference yield:

hex-5-ynoic acid (53293-00-8) + C33H41F2NO18 (1415238-60-6) → 4-(hex-5-yneamide)-2-difluromethyl-1-phenoxyl-2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose (1415238-68-4)

Guidance literature:

hex-5-ynoic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.25h; Inert atmosphere;

C₃₃H₄₁F₂NO₁₈; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ja309790w

Reference yield:

C33H41F2NO18 (1415238-60-6) → 4-(hex-5-yneamide)-2-difluromethyl 1-deoxy-1-phenoxyl-α-D-lactopyranose (1415238-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

2.2: amberlite IR-15 H+ resin / Inert atmosphere

With 4-methyl-morpholine; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja309790w

upstream raw materials:

2-formyl-4-nitro 2,3,4,6,2′ ,3′,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

Downstream raw materials:

4-(hex-5-yneamide)-2-difluromethyl 1-deoxy-1-phenoxyl-α-D-lactopyranose

4-(hex-5-yneamide)-2-difluromethyl-1-phenoxyl-2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose