N^α-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester

Base Information

• Chemical Name: N^α-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester
• CAS No.: 109889-13-6
• Molecular Formula: C₃₇H₄₅N₉O₁₀S₂
• Molecular Weight: 839.951

Synonyms:

Chemical Property of N^α-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester

There total 13 articles about N^α-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carboxylic acid (108998-85-2) + erithro-β-tert-butoxy-L-histidine-tert-butyl ester hydrochloride (101485-30-7,118130-93-1) → Nα-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester (109889-13-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 0 deg C, 1 h, then RT, 12 h;

DOI:10.1016/S0040-4020(88)90018-X

Reference yield: 36.0%

6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carboxylic acid (108998-85-2) + erythro-β-tert-Butoxy-L-histidine tert-butyl ester (101485-28-3) → (2S,3R)-3-tert-Butoxy-2-[(6-{[[(S)-2-carbamoyl-2-(2-nitro-phenylsulfanylamino)-ethyl]-(2-nitro-phenylsulfanyl)-amino]-methyl}-4-methoxy-pyridine-2-carbonyl)-amino]-3-(1H-imidazol-4-yl)-propionic acid tert-butyl ester (109889-13-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1016/S0040-4039(00)84868-6

Reference yield:

dimethyl 4-methoxypyridine-2,6-dicarboxylate (19872-93-6) → Nα-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester (109889-13-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 85 percent / NaBH₄ / methanol / 0 deg C to RT, 3 h

2: 1.) (COCl)2, 2.) Et₃N / 1.) DMSO, CH₂Cl₂, -30 deg C, 20 min, 2.) -60 deg C, 25 min, then RT

3: 89 percent

4: 86 percent / trifluoroacetic acid, Et₃N / CH₂Cl₂ / 0 deg C, 30 min, then RT, 6 h

5: 62 percent / LiOH / tetrahydrofuran / 0 deg C, then RT, 3 h

6: 36 percent / DCC, HOBt, N-methylmorpholine / dimethylformamide / 0 deg C, 1 h, then RT, 12 h

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; oxalyl dichloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(88)90018-X

upstream raw materials:

6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carboxylic acid

erythro-β-tert-Butoxy-L-histidine tert-butyl ester

dimethyl 4-methoxypyridine-2,6-dicarboxylate

Methyl 6-formyl-4-methoxypyridine-2-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 109889-13-6 N^α-<6-<ethyl>-N-(o-nitrophenylthio)amino>methyl>-4-methoxypyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send