Technology Process of (rac)-(E)-4-(1,2-dihydroxy-2,6,6-trimethylcyclohexyl)but-3-en-2-one
There total 17 articles about (rac)-(E)-4-(1,2-dihydroxy-2,6,6-trimethylcyclohexyl)but-3-en-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-β-ionone;
With
dihydrogen peroxide; ethyl acetate;
In
water;
at 20 ℃;
for 5h;
pH=3.0 - 4.0;
Green chemistry;
With
water;
at 20 ℃;
for 8h;
diastereoselective reaction;
Green chemistry;
DOI:10.1039/c9gc03208h
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / HCrO4(1-)*H3O(1+) / diethyl ether
2: 41 percent / 98percent aq. hydrazine hydrate / methanol / 2 h, -5 deg C then 16 h, 5 deg C
3: 90percent m-chloroperbenzoic acid / tetrahydrofuran / 20 h / Ambient temperature
4: 1.) DIBAL; 2.) manganese dioxid / 1.) ether/THF, 5 h, rt.; 2.) ethylacetat, rt., 40 min
With
manganese(IV) oxide; HCrO4(1-)*H3O(1+); diisobutylaluminium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether;
DOI:10.1002/hlca.19810640826
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / t-BuOOH/VO(AcAc)2 / benzene
2: 89 percent / HCrO4(1-)*H3O(1+) / diethyl ether
3: 41 percent / 98percent aq. hydrazine hydrate / methanol / 2 h, -5 deg C then 16 h, 5 deg C
4: 90percent m-chloroperbenzoic acid / tetrahydrofuran / 20 h / Ambient temperature
5: 1.) DIBAL; 2.) manganese dioxid / 1.) ether/THF, 5 h, rt.; 2.) ethylacetat, rt., 40 min
With
tert.-butylhydroperoxide; manganese(IV) oxide; bis(acetylacetonate)oxovanadium; HCrO4(1-)*H3O(1+); diisobutylaluminium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1002/hlca.19810640826
