(6R)-3-((Ξ)-3-acetyl-5-methylamino-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

• Chemical Name: (6R)-3-((Ξ)-3-acetyl-5-methylamino-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS No.: 73123-99-6
• Molecular Formula: C₃₁H₂₉N₅O₅S₃
• Molecular Weight: 647.8
• Mol file: 73123-99-6.mol

Synonyms:

Chemical Property of (6R)-3-((Ξ)-3-acetyl-5-methylamino-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R)-3-((Ξ)-3-acetyl-5-methylamino-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 1 articles about (6R)-3-((Ξ)-3-acetyl-5-methylamino-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + benzhydryl 3-(4-methylaminothiocarbonylhydrazonomethyl)-7-thienylacetamidoceph-3-em-4-carboxylate (62543-56-0) → (6R)-3-((Ξ)-3-acetyl-5-methylamino-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (73123-99-6)

Guidance literature:

In acetic acid;

DOI:10.1248/cpb.27.2544

Reference yield:

(6R)-3-((Ξ)-3-acetyl-5-methylamino-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (73123-99-6) → benzhydryl 3-(5-methylamino-1,3,4-thiadiazol-2-yl)-7-thienylacetamidoceph-3-em-4-carboxylate (62543-62-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane;

DOI:10.1248/cpb.27.2544

upstream raw materials:

acetic anhydride

benzhydryl 3-(4-methylaminothiocarbonylhydrazonomethyl)-7-thienylacetamidoceph-3-em-4-carboxylate

Downstream raw materials:

benzhydryl 3-(5-methylamino-1,3,4-thiadiazol-2-yl)-7-thienylacetamidoceph-3-em-4-carboxylate