Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester

Base Information

• Chemical Name: Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester
• CAS No.: 131451-68-8
• Molecular Formula: C₄₈H₅₈O₆Si
• Molecular Weight: 759.07
• Mol file: 131451-68-8.mol

Synonyms:

Chemical Property of Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester

There total 5 articles about Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (1R,4S,4aR,8R,8aR)-8-acetoxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester (131451-66-6) → Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester (131451-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) LDA

2: 100 percent / LiAlH₄ / tetrahydrofuran

3: 85 percent / pyridine

4: pyridine

With pyridine; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)97640-8

Reference yield:

C27H50O5Si2 (131451-61-1) → Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester (131451-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran

2: 85 percent / pyridine

3: pyridine

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)97640-8

Reference yield:

trityl chloride (76-83-5) → Acetoxy-phenyl-acetic acid (1S,4aS,5R,6R,8aS)-5-(tert-butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester (131451-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine

2: pyridine

With pyridine;

DOI:10.1016/S0040-4039(00)97640-8

upstream raw materials:

(1S,4aS,5R,6R,8aS)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(2-trityloxy-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-ol

2-acetoxy-2-phenylacetyl chloride

trityl chloride

Acetic acid (1R,4S,4aR,8R,8aR)-8-acetoxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester