AMG-337

Base Information

• Chemical Name: AMG-337
• CAS No.: 1173699-31-4
• Molecular Formula: C₂₃H₂₂FN₇O₃
• Molecular Weight: 463.471
• Mol file: 1173699-31-4.mol

Synonyms:

Chemical Property of AMG-337

Chemical Property:

• PKA: 2.10±0.20(Predicted)
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

AMG337 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: AMG 337 is a potent and selective inhibitor of mesencymal epethelial transition factor (MET factor) which has been implicated in several cancers.

Technology Process of AMG-337

There total 44 articles about AMG-337 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

C23H24FN7O4 → AMG 337 (1173699-31-4)

Guidance literature:

With trimethylsilylazide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 - 33 ℃; for 0.833333h;

Reference yield: 48.0%

C23H24FN7O4 → 6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (1173699-31-4)

Guidance literature:

With trimethylsilylazide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 23 ℃; for 0.833333h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01716

Reference yield:

(R)-N'-(3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-(3-(2-methoxyethoxy)-5-oxo-1,6-naphthyridin-6(5H)-yl)propanehydrazide → AMG 337 (1173699-31-4)

Guidance literature:

With Lawessons reagent; In water; acetonitrile; at 50 ℃; Inert atmosphere;

upstream raw materials:

ethyl 5-bromo-2-methyl-pyridine-3-carboxylate

3-bromo-7,8-dihydro-l,6-naphthyridin-5(6H)-one

4-amino-2-methoxypyridine

C₁₁H₁₆N₂O₂