Benzeneethanol,β-aMino-3-chloro- (hydrochloride)(1:1)

Base Information

• Chemical Name: Benzeneethanol,β-aMino-3-chloro- (hydrochloride)(1:1)
• CAS No.: 1334146-19-8
• Molecular Formula: C₈H₁₀ClNO*ClH
• Molecular Weight: 208.087
• Mol file: 1334146-19-8.mol

Synonyms:

Chemical Property of Benzeneethanol,β-aMino-3-chloro- (hydrochloride)(1:1)

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-2-(3-chlorophenyl)ethanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanol,β-aMino-3-chloro- (hydrochloride)(1:1)

There total 1 articles about Benzeneethanol,β-aMino-3-chloro- (hydrochloride)(1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-(3-chlorophenyl)-2-((4-methoxyphenyl)amino)ethan-1-ol → 1-(3-chlorophenyl)-2-hydroxyethan-1-aminium chloride (1245623-78-2,1334146-19-8)

Guidance literature:

2-(3-chlorophenyl)-2-((4-methoxyphenyl)amino)ethan-1-ol; With trichloroisocyanuric acid; sulfuric acid; In water; at 25 ℃; for 12h;

With hydrogenchloride; In water; at 25 ℃; for 1h;

DOI:10.1021/acs.orglett.9b01913

Reference yield: 20.0%

2-(S)-amino-2-(3-chloro-phenyl)-ethanol hydrochloride (620616-08-2,1245623-78-2,1334146-19-8) + ethyl acetoacetate (141-97-9) + N-cyanodiphenylcarbonimidate (79463-77-7) + acetic acid (64-19-7,77671-22-8) → C16H16ClN5O3 + (S)-2-((1-(3-chlorophenyl)-2-hydroxyethyl)amino)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:

2-(S)-amino-2-(3-chloro-phenyl)-ethanol hydrochloride; N-cyanodiphenylcarbonimidate; With triethylamine; In isopropyl alcohol; at 60 ℃; for 2.5h;

With hydrazine hydrate; In isopropyl alcohol; at 20 - 50 ℃;

ethyl acetoacetate; acetic acid; at 165 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.7b01691

Reference yield:

2-(S)-amino-2-(3-chloro-phenyl)-ethanol hydrochloride (620616-08-2,1245623-78-2,1334146-19-8) → (S)-2-(3-chlorophenyl)-2-((5-methyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino)ethyl carbamate

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / isopropyl alcohol / 2.5 h / 60 °C

1.2: 20 - 50 °C

1.3: 0.17 h / 165 °C / Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.7b01691

Refernces