(1RS,2RS)-1-cyclohexyl-2-methyl-3-buten-1-ol

Base Information

• Chemical Name: (1RS,2RS)-1-cyclohexyl-2-methyl-3-buten-1-ol
• CAS No.: 93965-65-2
• Molecular Formula: C₁₁H₂₀O
• Molecular Weight: 168.279
• Mol file: 93965-65-2.mol

Synonyms:

Chemical Property of (1RS,2RS)-1-cyclohexyl-2-methyl-3-buten-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1RS,2RS)-1-cyclohexyl-2-methyl-3-buten-1-ol

There total 62 articles about (1RS,2RS)-1-cyclohexyl-2-methyl-3-buten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-chloro-2-butene (591-97-9) + cyclohexanecarbaldehyde (2043-61-0) → 1-cyclohexyl-2-methylbut-3-en-1-ol (93965-64-1,93965-65-2,106650-99-1,106651-03-0,121155-51-9,121155-52-0,121842-21-5)

Guidance literature:

With bis(cyclopentadienyl)titanium dichloride; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In tetrahydrofuran; at 20 ℃; for 12h; regioselective reaction; Inert atmosphere; Irradiation;

DOI:10.1055/s-0040-1706024

Reference yield: 85.0%

1-cyclohexyl-2-methyl-3-trimethylsilanyl-but-3-en-1-ol → 1-cyclohexyl-2-methyl-but-3-en-1-ol (93965-64-1,93965-65-2,106650-99-1,106651-03-0,121155-51-9,121155-52-0,121842-21-5)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; In tetrahydrofuran; kerosene; at 25 ℃; for 2h;

DOI:10.1039/b802157k

Reference yield:

(E)-but-2-enol (504-61-0,542-72-3) + cyclohexanecarbaldehyde (2043-61-0) → 1-cyclohexyl-2-methylbut-3-en-1-ol (93965-64-1,93965-65-2,106650-99-1,106651-03-0,121155-51-9,121155-52-0,121842-21-5) + (1RS,2RS)-1-cyclohexyl-2-methyl-3-buten-1-ol (93965-64-1,93965-65-2,106650-99-1,106651-03-0,121155-51-9,121155-52-0,121842-21-5)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; tin(ll) chloride; In various solvent(s); at 25 ℃; for 72h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

crotyltributylstannane

cyclohexanecarbaldehyde

1-cyclohexyl-2-methyl-3-butyn-1-ol

(E)-but-2-enol

Downstream raw materials:

(1RS,2SR)-N-phenylmethyl-1-cyclohexyl-2-methyl-3-buten-1-amine

(1RS,2RS)-N-phenylmethyl-1-cyclohexyl-2-methyl-3-buten-1-amine

trans-1-cyclohexyl-2-methyl-1,4-butanediol