Technology Process of 4',5-diacetoxy-2',5'-dimethoxy-2,2-dimethylpyrano<6,5-h>isoflavone
There total 9 articles about 4',5-diacetoxy-2',5'-dimethoxy-2,2-dimethylpyrano<6,5-h>isoflavone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / K2CO3 / dimethylformamide / 1 h / 140 °C
2: 1.) POCl3 / 1.) 10 deg C, 2.) ClCH2CH2Cl
3: 48 percent / piperidine / ethanol / 6 h / Heating
4: 84 percent / pyridine
5: 1.) thallium(III) nitrate trihydrate, 2.) 10 percent hydrochloric acid / 1.) MeOH, 35 - 36 deg C, 7 h, 2.) MeOH, reflux, 3 h
6: 89 percent / hydrogen / 10 5 palladium/charcoal / methanol; ethyl acetate
7: 51 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / chlorobenzene / 2 h / 140 °C
8: 82 percent / pyridine
With
piperidine; pyridine; hydrogenchloride; thallium(III) nitrate trihydrate; hydrogen; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate;
palladium on activated charcoal;
In
methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1248/cpb.36.592
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) POCl3 / 1.) 10 deg C, 2.) ClCH2CH2Cl
2: 48 percent / piperidine / ethanol / 6 h / Heating
3: 84 percent / pyridine
4: 1.) thallium(III) nitrate trihydrate, 2.) 10 percent hydrochloric acid / 1.) MeOH, 35 - 36 deg C, 7 h, 2.) MeOH, reflux, 3 h
5: 89 percent / hydrogen / 10 5 palladium/charcoal / methanol; ethyl acetate
6: 51 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / chlorobenzene / 2 h / 140 °C
7: 82 percent / pyridine
With
piperidine; pyridine; hydrogenchloride; thallium(III) nitrate trihydrate; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate;
palladium on activated charcoal;
In
methanol; ethanol; ethyl acetate; chlorobenzene;
DOI:10.1248/cpb.36.592
