6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester

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Chemical Name:6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester
CAS No.:83009-67-0
Molecular Formula:C₃₇H₅₈O₆SSi
Molecular Weight:659.015
Hs Code.:

6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester

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Chemical Property of 6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester

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Technology Process of 6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester

There total 6 articles about 6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17689-17-7
6-mercaptocaproic acid

: 83009-67-0,83059-48-7
6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / triethylamine / methanol

2: 77 percent / dicyclohexylcarbodiimide, pyridine / CH₂Cl₂ / 18 h / Ambient temperature

3: 1.) 2.0 M tert-BuLi, phenylthiocopper, (Me₂N)3P / 1.) pentane, ether; 2.) pentane, THF, ether

With pyridine; tert.-butyl lithium; copper(I) thiophenolate; triethylamine; dicyclohexyl-carbodiimide; Hexamethylphosphorous triamide; In methanol; dichloromethane;
DOI:10.1248/cpb.33.2359

Reference yield:

: 64079-54-5
4-(2-tetrahydropyranyloxy)-2,3-epoxycyclopentan-1-one

: 83009-67-0,83059-48-7
6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / triethylamine / methanol

2: 77 percent / dicyclohexylcarbodiimide, pyridine / CH₂Cl₂ / 18 h / Ambient temperature

3: 1.) 2.0 M tert-BuLi, phenylthiocopper, (Me₂N)3P / 1.) pentane, ether; 2.) pentane, THF, ether

With pyridine; tert.-butyl lithium; copper(I) thiophenolate; triethylamine; dicyclohexyl-carbodiimide; Hexamethylphosphorous triamide; In methanol; dichloromethane;
DOI:10.1248/cpb.33.2359

Reference yield:

: 83009-40-9
dl-2-(5-carboxypentylthio)-4-(tetrahydropyran-2-yloxy)-2-cyclopentenone

: 83009-67-0,83059-48-7
6-[2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propenyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentylsulfanyl]-hexanoic acid phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / dicyclohexylcarbodiimide, pyridine / CH₂Cl₂ / 18 h / Ambient temperature

2: 1.) 2.0 M tert-BuLi, phenylthiocopper, (Me₂N)3P / 1.) pentane, ether; 2.) pentane, THF, ether

With pyridine; tert.-butyl lithium; copper(I) thiophenolate; dicyclohexyl-carbodiimide; Hexamethylphosphorous triamide; In dichloromethane;
DOI:10.1248/cpb.33.2359